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吳志強(qiáng)

研究員

導(dǎo)師類別：博士生導(dǎo)師

性別：男

學(xué)歷：博士研究生

學(xué)位：博士

個(gè)人簡(jiǎn)介

吳志強(qiáng)，男，博士，研究員，博士研究生導(dǎo)師
北京協(xié)和醫(yī)學(xué)院病原生物學(xué)研究所課題組長(zhǎng)
國(guó)家高層次人才特殊支持計(jì)劃“萬(wàn)人計(jì)劃”青年拔尖人才獲得者
北京協(xié)和醫(yī)學(xué)院“協(xié)和新星”
主持和承擔(dān)國(guó)家科技重大專項(xiàng)、國(guó)家重點(diǎn)研發(fā)計(jì)劃、國(guó)家自然科學(xué)基金和北京市自然科學(xué)基金等多項(xiàng)國(guó)家級(jí)和省部級(jí)課題；作為第一/通訊作者在The Lancet、National Science Review、Nature Communications、Microbiome、ISME Journal、Nucleic Acids Research、Journal of Virology等雜志發(fā)表SCI論文四十余篇；獲得國(guó)家發(fā)明專利2項(xiàng)，軟件著作權(quán)1項(xiàng)；獲得省部級(jí)科技獎(jiǎng)勵(lì)二等獎(jiǎng)2項(xiàng)，三等獎(jiǎng)1項(xiàng)。

研究方向

動(dòng)物源性新發(fā)病毒的監(jiān)測(cè)、預(yù)警和溯源研究。

科研項(xiàng)目

1. 菲菊頭蝠攜帶冠狀病毒進(jìn)化、重組及跨種適應(yīng)特征研究，國(guó)家自然科學(xué)基金面上項(xiàng)目。
2. 潛在威脅人類病原體發(fā)現(xiàn)與挖掘-嚙齒目、靈長(zhǎng)目生態(tài)圈病原體廣域調(diào)查與全鏈條挖掘，國(guó)家重點(diǎn)研發(fā)計(jì)劃。
3. 蝙蝠攜帶病毒多樣性及其跨種適應(yīng)機(jī)制研究，國(guó)家重點(diǎn)研發(fā)計(jì)劃。
4. 2019-nCoV溯源和傳播途徑研究，國(guó)家重點(diǎn)研發(fā)計(jì)劃。
5. 以野生動(dòng)物病毒組學(xué)為基礎(chǔ)的新型冠狀病毒溯源及其變異進(jìn)化研究，北京市自然科學(xué)基金面上專項(xiàng)。
6. 我國(guó)周邊地區(qū)重要傳染病防控及處置能力提升研究，國(guó)家科技重大專項(xiàng)。
7. 中國(guó)代表性嚙齒目及其他類小動(dòng)物攜帶病毒的病毒組學(xué)研究，國(guó)家自然科學(xué)基金面上項(xiàng)目。
8. 我國(guó)蚊媒攜帶病毒組特征及傳染病預(yù)警溯源關(guān)聯(lián)研究，中國(guó)醫(yī)學(xué)科學(xué)院中央級(jí)公益性科研院所基本科研業(yè)務(wù)費(fèi)青年醫(yī)學(xué)人才獎(jiǎng)勵(lì)項(xiàng)目。
9. 新型鼠源性砂粒病毒的鑒定及淋巴細(xì)胞脈絡(luò)叢腦膜炎病毒的基因結(jié)構(gòu)比較和進(jìn)化研究，國(guó)家自然科學(xué)基金青年科學(xué)基金。

研究成果

1.Han Y, Xu P, Wang Y, Zhao W, Zhang J, Zhang S, Wang J, Jin Q, Wu Z. 2023. . Nat Commun 14:5537.

2. Wu Z, Han Y, Wang Y, Liu B, Zhao L, Zhang J, Su H, Zhao W, Liu L, Bai S, Dong J, Sun L, Zhu Y, Zhou S, Song Y, Sui H, Yang J, Wang J, Zhang S, Qian Z, Jin Q. 2023. A comprehensive survey of bat sarbecoviruses across China in relation to the origins of SARS-CoV and SARS-CoV-2. Natl Sci Rev 10:nwac213.

3. Su H, Wang Y, Han Y, Jin Q, Yang F, Wu Z. 2023. Discovery and characterization of novel paramyxoviruses from bat samples in China. Virol Sin 38:198-207.

4. Ou X, Xu G, Li P, Liu Y, Zan F, Liu P, Hu J, Lu X, Dong S, Zhou Y, Mu Z, Wu Z, Wang J, Jin Q, Liu P, Lu J, Wang X, Qian Z. 2023. Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses. Cell Discov 9:78.

5. Liu WJ, Lei W, He X, Liu P, Wang Q, Wu Z, Tan Y, Song S, Wong G, Lu J, Jiang J, Wei Q, Li M, Ma J, Peng X, Li Y, Huang B, Tong Y, Han J, Wu G. 2023. Back to Science in Searching for SARS-CoV-2 Origins. China CDC Wkly 5:315-317.

6. Li Y, Tang C, Zhang Y, Li Z, Wang G, Peng R, Huang Y, Hu X, Xin H, Feng B, Cao X, He Y, Guo T, He Y, Su H, Cui X, Niu L, Wu Z, Yang J, Yang F, Lu G, Gao L, Jin Q, Xiao M, Yin F, Du J. 2023. Diversity and independent evolutionary profiling of rodent-borne viruses in Hainan, a tropical island of China. Virol Sin doi:10.1016/j.virs.2023.08.003.

7. Li P, Hu J, Liu Y, Ou X, Mu Z, Lu X, Zan F, Cao M, Tan L, Dong S, Zhou Y, Lu J, Jin Q, Wang J, Wu Z, Zhang Y, Qian Z. 2023. Effect of polymorphism in Rhinolophus affinis ACE2 on entry of SARS-CoV-2 related bat coronaviruses. PLoS Pathog 19:e1011116.

8. Zhou S, Liu B, Han Y, Wang Y, Chen L, Wu Z, Yang J. 2022. ZOVER: the database of zoonotic and vector-borne viruses. Nucleic Acids Res 50:D943-d949.

9. Wu Z, Jin Q, Wu G, Lu J, Li M, Guo D, Lan K, Feng L, Qian Z, Ren L, Tan W, Xu W, Yang W, Wang J, Wang C. 2021. SARS-CoV-2's origin should be investigated worldwide for pandemic prevention. Lancet 398:1299-1303.

10. Wu Z, Han Y, Liu B, Li H, Zhu G, Latinne A, Dong J, Sun L, Su H, Liu L, Du J, Zhou S, Chen M, Kritiyakan A, Jittapalapong S, Chaisiri K, Buchy P, Duong V, Yang J, Jiang J, Xu X, Zhou H, Yang F, Irwin DM, Morand S, Daszak P, Wang J, Jin Q. 2021. Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia. Microbiome 9:18.

11. Wang G, Huang Y, Zhang W, Peng R, Luo J, Liu S, Bai S, Hu X, Wu Z, Yang F, Shen S, Zhang Y, Tang C, Cui X, Niu L, Lu G, Li S, Deng F, Zhang P, Du J, Yin F. 2021. Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China. Sci Rep 11:21018.

12. Liu Y, Liu B, Liu C, Hu Y, Liu C, Li X, Li X, Zhang X, Irwin DM, Wu Z, Chen Z, Jin Q, Zhang S. 2021. Differences in the gut microbiomes of dogs and wolves: roles of antibiotics and starch. BMC Vet Res 17:112.

13. Li P, Guo R, Liu Y, Zhang Y, Hu J, Ou X, Mi D, Chen T, Mu Z, Han Y, Chen Z, Cui Z, Zhang L, Wang X, Wu Z, Wang J, Jin Q, Qian Z. 2021. The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2. Sci Bull (Beijing) 66:1215-1227.

14. Ren LL, Wang YM, Wu ZQ, Xiang ZC, Guo L, Xu T, Jiang YZ, Xiong Y, Li YJ, Li XW, Li H, Fan GH, Gu XY, Xiao Y, Gao H, Xu JY, Yang F, Wang XM, Wu C, Chen L, Liu YW, Liu B, Yang J, Wang XR, Dong J, Li L, Huang CL, Zhao JP, Hu Y, Cheng ZS, Liu LL, Qian ZH, Qin C, Jin Q, Cao B, Wang JW. 2020. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J (Engl) 133:1015-1024.

15. Li F, Du J, Wu Z, Zhang W, Fu S, Song J, Wang Q, He Y, Lei W, Xu S, Xu A, Zhao L, Liang G, Wang H. 2020. Identification and genetic analysis of a totivirus isolated from the Culex tritaeniorhynchus in northern China. Arch Microbiol 202:807-813.

16. Kuhn JH, Adkins S, Alioto D, Alkhovsky SV, Amarasinghe GK, Anthony SJ, Avši?-?upanc T, Ayllón MA, Bahl J, Balkema-Buschmann A, Ballinger MJ, Bartoni?ka T, Basler C, Bavari S, Beer M, Bente DA, Bergeron É, Bird BH, Blair C, Blasdell KR, Bradfute SB, Breyta R, Briese T, Brown PA, Buchholz UJ, Buchmeier MJ, Bukreyev A, Burt F, Buzkan N, Calisher CH, Cao M, Casas I, Chamberlain J, Chandran K, Charrel RN, Chen B, Chiumenti M, Choi IR, Clegg JCS, Crozier I, da Graça JV, Dal Bó E, Dávila AMR, de la Torre JC, de Lamballerie X, de Swart RL, Di Bello PL, Di Paola N, Di Serio F, Dietzgen RG, et al. 2020. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Arch Virol 165:3023-3072.

17. Du J, Li F, Han Y, Fu S, Liu B, Shao N, Su H, Zhang W, Zheng D, Lei W, Dong J, Sun L, He Y, Wang J, Yang F, Wang H, Liang G, Wu Z, Jin Q. 2020. Characterization of viromes within mosquito species in China. Sci China Life Sci 63:1089-1092.

18. Han Y, Du J, Su H, Zhang J, Zhu G, Zhang S, Wu Z, Jin Q. 2019. Identification of Diverse Bat Alphacoronaviruses and Betacoronaviruses in China Provides New Insights Into the Evolution and Origin of Coronavirus-Related Diseases. Front Microbiol 10:1900.

19. Wu Z, Lu L, Du J, Yang L, Ren X, Liu B, Jiang J, Yang J, Dong J, Sun L, Zhu Y, Li Y, Zheng D, Zhang C, Su H, Zheng Y, Zhou H, Zhu G, Li H, Chmura A, Yang F, Daszak P, Wang J, Liu Q, Jin Q. 2018. Comparative analysis of rodent and small mammal viromes to better understand the wildlife origin of emerging infectious diseases. Microbiome 6:178.

20. Wu Z, Liu B, Du J, Zhang J, Lu L, Zhu G, Han Y, Su H, Yang L, Zhang S, Liu Q, Jin Q. 2018. Discovery of Diverse Rodent and Bat Pestiviruses With Distinct Genomic and Phylogenetic Characteristics in Several Chinese Provinces. Front Microbiol 9:2562.

21. Wu Z, Du J, Lu L, Yang L, Dong J, Sun L, Zhu Y, Liu Q, Jin Q. 2018. Detection of Hantaviruses and Arenaviruzses in three-toed jerboas from the Inner Mongolia Autonomous Region, China. Emerg Microbes Infect 7:35.

22. Maes P, Alkhovsky SV, Bào Y, Beer M, Birkhead M, Briese T, Buchmeier MJ, Calisher CH, Charrel RN, Choi IR, Clegg CS, de la Torre JC, Delwart E, DeRisi JL, Di Bello PL, Di Serio F, Digiaro M, Dolja VV, Drosten C, Druciarek TZ, Du J, Ebihara H, Elbeaino T, Gergerich RC, Gillis AN, Gonzalez JJ, Haenni AL, Hepojoki J, Hetzel U, H? T, Hóng N, Jain RK, Jansen van Vuren P, Jin Q, Jonson MG, Junglen S, Keller KE, Kemp A, Kipar A, Kondov NO, Koonin EV, Kormelink R, Korzyukov Y, Krupovic M, Lambert AJ, Laney AG, LeBreton M, Lukashevich IS, Marklewitz M, Markotter W, et al. 2018. Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018. Arch Virol 163:2295-2310.

23. Du J, Li Y, Lu L, Zheng D, Liu B, Yang L, Su H, Dong J, Sun L, Zhu Y, Yang J, Yang F, Zhang X, Liu Q, Wu Z, Jin Q. 2018. Biodiversity of rodent anelloviruses in China. Emerg Microbes Infect 7:38.

24. Xiu L, Zhang C, Wu Z, Peng J. 2017. Establishment and Application of a Universal Coronavirus Screening Method Using MALDI-TOF Mass Spectrometry. Front Microbiol 8:1510.

25. Chen L, Liu B, Wu Z, Jin Q, Yang J. 2017. DRodVir: A resource for exploring the virome diversity in rodents. J Genet Genomics 44:259-264.

26. Wu Z, Yang L, Ren X, Zhang J, Yang F, Zhang S, Jin Q. 2016. ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus. J Infect Dis 213:579-83.

27. Wu Z, Yang L, Ren X, He G, Zhang J, Yang J, Qian Z, Dong J, Sun L, Zhu Y, Du J, Yang F, Zhang S, Jin Q. 2016. Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases. Isme j 10:609-20.

28. Du J, Yang L, Ren X, Zhang J, Dong J, Sun L, Zhu Y, Yang F, Zhang S, Wu Z, Jin Q. 2016. Genetic diversity of coronaviruses in Miniopterus fuliginosus bats. Sci China Life Sci 59:604-14.

29. Du J, Lu L, Liu F, Su H, Dong J, Sun L, Zhu Y, Ren X, Yang F, Guo F, Liu Q, Wu Z, Jin Q. 2016. Distribution and characteristics of rodent picornaviruses in China. Sci Rep 6:34381.

30. Li JL, Yuan J, Yang F, Wu ZQ, Hu YF, Xue Y, Zhou BP, Jin Q. 2014. Epidemic characteristics of hand, foot, and mouth disease in southern China, 2013: coxsackievirus A6 has emerged as the predominant causative agent. J Infect 69:299-303.

31. Wu Z, Du J, Zhang T, Xue Y, Yang F, Jin Q. 2013. Recombinant human coxsackievirus B3 from children with acute myocarditis in China. J Clin Microbiol 51:3083-6.

32. Wang J, Du J, Wu Z, Jin Q. 2013. Quinacrine impairs enterovirus 71 RNA replication by preventing binding of polypyrimidine-tract binding protein with internal ribosome entry sites. PLoS One 8:e52954.

33. Du J, Wu Z, Xue Y, Zhang T, Yang F, Jin Q. 2013. Complete genome sequence of a human coxsackievirus b3 from a child with myocarditis in beijing, china. Genome Announc 1.

34. Zhang T, Wu Z, Du J, Hu Y, Liu L, Yang F, Jin Q. 2012. Anti-Japanese-encephalitis-viral effects of kaempferol and daidzin and their RNA-binding characteristics. PLoS One 7:e30259.

35. Wu Z, Ren X, Yang L, Hu Y, Yang J, He G, Zhang J, Dong J, Sun L, Du J, Liu L, Xue Y, Wang J, Yang F, Zhang S, Jin Q. 2012. Virome analysis for identification of novel mammalian viruses in bat species from Chinese provinces. J Virol 86:10999-1012.

36. Wang J, Wu Z, Jin Q. 2012. COPI is required for enterovirus 71 replication. PLoS One 7:e38035.

37. Chen LH, Wu ZQ, Hu YF, Yang F, Yang J, Jin Q. 2012. [Genetic diversity of adenoviruses in bats of China]. Bing Du Xue Bao 28:403-8.

38. Yang J, Yang F, Ren L, Xiong Z, Wu Z, Dong J, Sun L, Zhang T, Hu Y, Du J, Wang J, Jin Q. 2011. Unbiased parallel detection of viral pathogens in clinical samples by use of a metagenomic approach. J Clin Microbiol 49:3463-9.

39. Wu Z, Xue Y, Wang B, Du J, Jin Q. 2011. Broad-spectrum antiviral activity of RNA interference against four genotypes of Japanese encephalitis virus based on single microRNA polycistrons. PLoS One 6:e26304.

40. Wang J, Fan T, Yao X, Wu Z, Guo L, Lei X, Wang J, Wang M, Jin Q, Cui S. 2011. Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues. J Virol 85:10021-30.

41. Zhiqiang W, Yaowu Y, Fan Y, Jian Y, Yongfeng H, Lina Z, Jianwei W, Qi J. 2010. Effective siRNAs inhibit the replication of novel influenza A (H1N1) virus. Antiviral Res 85:559-61.

42. Wu Z, Yang F, Zhao R, Zhao L, Guo D, Jin Q. 2009. Identification of small interfering RNAs which inhibit the replication of several Enterovirus 71 strains in China. J Virol Methods 159:233-8.

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研究生培養(yǎng)

在讀博士研究生：韓業(yè)林（2021級(jí)），黎蕊（2022級(jí)），趙臘梅（2023級(jí)），于秀娟（2023級(jí)）
在讀碩士研究生：許盼盼（2021級(jí)）。
已畢業(yè)博士研究生：杜江（2014級(jí)），王宇洋（2020級(jí)）。
已畢業(yè)碩士研究生：韓業(yè)林（2017級(jí)）
1人次獲得國(guó)家獎(jiǎng)學(xué)金，2人次獲得一等獎(jiǎng)學(xué)金、優(yōu)秀研究生，2人次獲得北京協(xié)和醫(yī)學(xué)院中央高校基本科研業(yè)務(wù)費(fèi)（學(xué)生項(xiàng)目）資助。