人才隊(duì)伍
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劉海鷹
個(gè)人簡介
中國醫(yī)學(xué)科學(xué)院/北京協(xié)和醫(yī)學(xué)院病原生物學(xué)研究所黨委副書記、紀(jì)委書記、課題組組長。全國結(jié)核病防治綜合質(zhì)量控制專家指導(dǎo)委員會(huì)委員、中國免疫學(xué)會(huì)感染免疫分會(huì)委員、中國防癆協(xié)會(huì)結(jié)核病基礎(chǔ)專業(yè)分會(huì)常委。《中華結(jié)核和呼吸雜志》和《結(jié)核與肺部疾病雜志》編委。
主要研究方向是感染、炎癥與免疫機(jī)制研究。主持或參與國家科技重大專項(xiàng)、國家重點(diǎn)研發(fā)計(jì)劃、國家自然科學(xué)基金、醫(yī)學(xué)與健康科技創(chuàng)新工程等多項(xiàng)國家級和院校級科研項(xiàng)目，參與多項(xiàng)戰(zhàn)略咨詢項(xiàng)目研究。在SCI收錄雜志上發(fā)表學(xué)術(shù)論文30余篇；獲得6項(xiàng)發(fā)明專利授權(quán)；獲得中華醫(yī)學(xué)科學(xué)技術(shù)獎(jiǎng)二等獎(jiǎng)（排名第五）、重大專項(xiàng)創(chuàng)新團(tuán)隊(duì)獎(jiǎng)。
研究方向
結(jié)核病等我國重大傳染病免疫機(jī)制及新型生物標(biāo)識的研究。
科研項(xiàng)目
1. 國家重點(diǎn)研發(fā)計(jì)劃（2021-2026），結(jié)核病新型診斷、治療、干預(yù)手段及產(chǎn)品研發(fā)，課題骨干。
2. 中國醫(yī)學(xué)科學(xué)院中央級公益性科研院所基本科研業(yè)務(wù)費(fèi)（2020-2022），西藏自治區(qū)結(jié)核病流行菌株特征及致病特點(diǎn)研究，課題負(fù)責(zé)人。
3. 國家自然科學(xué)基金委員會(huì)面上項(xiàng)目（2021-2024），血管生成素2參與活動(dòng)性肺結(jié)核免疫機(jī)制研究，課題負(fù)責(zé)人。
4. 中國工程院咨詢研究項(xiàng)目(2019-2020 )，中國與法國等發(fā)達(dá)國家結(jié)核病防治體系的對比研究，課題骨干。
5. 國家外專局高端外國專家項(xiàng)目(2018-1019)，結(jié)核病新型分子標(biāo)識研究，課題負(fù)責(zé)人。
6. 國家科技重大專項(xiàng) (2017-2020)，菌陰結(jié)核病和結(jié)核分枝桿菌潛伏感染相關(guān)生物標(biāo)志物研究，子課題負(fù)責(zé)人。
7. 中國醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與健康科技創(chuàng)新工程項(xiàng)目(2016-2021)，感染性疾病（結(jié)核病等）診治新策略研究，課題骨干。
8. 國家自然科學(xué)基金委員會(huì)面上項(xiàng)目(2012-2015)，接頭蛋白Gab2調(diào)控結(jié)核病發(fā)生、發(fā)展的免疫學(xué)功能研究，課題負(fù)責(zé)人。
9. 國家科技重大專項(xiàng) (2012-2015)，結(jié)核病分子標(biāo)識的研究，課題負(fù)責(zé)人。
10. 國家科技重大專項(xiàng)(2008-2010)，結(jié)核病免疫保護(hù)機(jī)制研究，課題負(fù)責(zé)人。
11. 國家科技重大專項(xiàng) (2008-2010)，結(jié)核病診斷分子標(biāo)識研究，子課題負(fù)責(zé)人。
研究成果
1. Dong, H., Y. Zhang, Y. Zou, Y. Chen, J. Yue, H. Liu and X. Jiang (2021). "Elevated chemokines concentration is associated with disease activity in Takayasu arteritis." Cytokine 143: 155515.
2. Li, H., L. Liu, W. J. Zhang, X. Zhang, J. Zheng, L. Li, X. Zhu, Q. Yang, M. Zhang, H. Liu, X. Chen and Q. Jin (2019). "Analysis of the Antigenic Properties of Membrane Proteins of Mycobacterium tuberculosis." Sci Rep 9(1): 3042.
3. Liu, C. H., H. Liu and B. Ge (2017). "Innate immunity in tuberculosis: host defense vs pathogen evasion." Cell Mol Immunol 14(12): 963-975.
4. Hu, Y., Y. Zhang, X. Ren, Y. Liu, Y. Xiao, L. Li, F. Yang, H. Su, F. Liu, H. Liu, B. Cao and Q. Jin (2016). "A case report demonstrating the utility of next generation sequencing in analyzing serial samples from the lung following an infection with influenza A (H7N9) virus." J Clin Virol 76: 45-50.
5. Yu, Y., D. Jin, S. Hu, Y. Zhang, X. Zheng, J. Zheng, M. Liao, X. Chen, M. Graner, H. Liu and Q. Jin (2015). "A novel tuberculosis antigen identified from human tuberculosis granulomas." Mol Cell Proteomics 14(4): 1093-1103.
6. Zhang, M., G. Zeng, Q. Yang, J. Zhang, X. Zhu, Q. Chen, P. Suthakaran, Y. Zhang, Q. Deng, H. Liu, B. Zhou and X. Chen (2014). "Anti-tuberculosis treatment enhances the production of IL-22 through reducing the frequencies of regulatory B cell." Tuberculosis (Edinb) 94(3): 238-244.
7. Liu, L., W. J. Zhang, J. Zheng, H. Fu, Q. Chen, Z. Zhang, X. Chen, B. Zhou, L. Feng, H. Liu and Q. Jin (2014). "Exploration of novel cellular and serological antigen biomarkers in the ORFeome of Mycobacterium tuberculosis." Mol Cell Proteomics 13(3): 897-906.
8. Hu, S., Y. Zhang, Y. Yu, D. Jin, X. Zhang, S. Gu, H. Jia, X. Chen, Z. Zhang, Q. Jin, Y. Ke and H. Liu (2014). "Growth factor receptor bound protein 2-associated binder 2, a scaffolding adaptor protein, negatively regulates host immunity against tuberculosis." Am J Respir Cell Mol Biol 51(4): 575-585.
9. Zhang, Y., H. Liu, L. Wang, F. Yang, Y. Hu, X. Ren, G. Li, Y. Yang, S. Sun, Y. Li, X. Chen, X. Li and Q. Jin (2013). "Comparative study of the cytokine/chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease." PLoS One 8(6): e67430.
10. Yu, Y., Y. Zhang, S. Hu, D. Jin, X. Chen, Q. Jin and H. Liu (2012). "Different patterns of cytokines and chemokines combined with IFN-gamma production reflect Mycobacterium tuberculosis infection and disease." PLoS One 7(9): e44944.
11. Qiu, Z., M. Zhang, Y. Zhu, F. Zheng, P. Lu, H. Liu, M. W. Graner, B. Zhou and X. Chen (2012). "Multifunctional CD4 T cell responses in patients with active tuberculosis." Sci Rep 2: 216.
12. Liu, K., Y. Zhang, S. Hu, Y. Yu, Q. Yang, D. Jin, X. Chen, Q. Jin and H. Liu (2012). "Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis." PLoS One 7(6): e38429.
13. Zhang, M., Z. Wang, M. W. Graner, L. Yang, M. Liao, Q. Yang, J. Gou, Y. Zhu, C. Wu, H. Liu, B. Zhou and X. Chen (2011). "B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis." Cell Immunol 270(2): 217-223.
14. Bai, X., K. Chmura, A. R. Ovrutsky, R. P. Bowler, R. I. Scheinman, R. E. Oberley-Deegan, H. Liu, S. Shang, D. Ordway and E. D. Chan (2011). "Mycobacterium tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription." Tuberculosis (Edinb) 91(1): 26-35.
15. Chen, X., M. Zhang, X. Zhu, Q. Deng, H. Liu, N. Larmonier, M. W. Graner and B. Zhou (2009). "Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy." J Infect Dis 200(3): 399-408.
16. Niedbala, W., B. Cai, H. Liu, N. Pitman, L. Chang, and F.Y. Liew, Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc Natl Acad Sci U S A, 2007. 104(39): p. 15478-83.
17. Liu, H. and B.P. Leung, CD4+CD25+ regulatory T cells in health and disease. Clin Exp Pharmacol Physiol, 2006. 33(5-6): p. 519-24.
18. Liu, H., M. Komai-Koma, D. Xu, and F.Y. Liew, Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A, 2006. 103(18): p. 7048-53.
19. Liew, F.Y., H. Liu, and D. Xu, A novel negative regulator for IL-1 receptor and Toll-like receptor 4. Immunol Lett, 2005. 96(1): p. 27-31.
20. Xu, D., H. Liu, and M. Komai-Koma, Direct and indirect role of Toll-like receptors in T cell mediated immunity. Cell Mol Immunol, 2004. 1(4): p. 239-46.
21. Brint, E.K., D. Xu, H. Liu, A. Dunne, A.N. McKenzie, L.A. O'Neill, and F.Y. Liew, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol, 2004. 5(4): p. 373-9
22. Xu, D., H. Liu, M. Komai-Koma, C. Campbell, C. McSharry, J. Alexander, and F.Y. Liew, CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol, 2003. 170(1): p. 394-9.
23. Liu, H., B. Hu, D. Xu, and F.Y. Liew, CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4. J Immunol, 2003. 171(10): p. 5012-7.
研究生培養(yǎng)
培養(yǎng)博士研究生4名，碩士研究生4名，3名碩士研究生在讀。